Category Archives: Business Leader

Sahm Adrangi: PTI-428 by Proteostasis is a Flop

If Sahm Adrangi’s past predictions on the success and failures of different medications in development stand correct, Proteostasis’ new medication in development, PTI-428, is doomed to failure. PTI-428 is a medication that is supposed to treat the serious ill cystic fibrosis which interferes with a patient’s ability to properly breathe. While their Phase 2 studies showed about a 5% increase in lung function, Sahm Adrangi and the experts at Kerrisdale Capital Management think this is mostly due to skewed data and a small placebo group. The trial which only lasted 28 days consisted of only 4 cystic fibrosis patients in the placebo group. Some of these patients experienced a dramatic drop in lung performance that sometimes naturally happens with the disease.

Unfortunately, this anomaly made the therapy group’s results look much better than they actually were. If the patients that experienced the drop in function were discluded from the results, the gap between the two groups would close significantly and the difference would only be around 1% according to Sahm Adrangi. These results would not impress anyone which is why Sahm Adrangi believes that the Proteostasis purposely omitted certain information from the results that were released to the general public. These skewed results may be a big reason why Proteostasis was avoiding a larger trial. Kerrisdale Capital adds that some important results such as sweat chloride are completely ignored or sloppy in the published results by Proteostasis. There are even questions from Sahm Adrangi and his team at Kerrisdale Capital on whether or not the biomarkers being used in the study could actually be properly measured by Proteostasis. To some, it’s doubtful that the company truly knows how their own drug is supposed to work.

Whether on its own or in conjunction with other drugs that are standards of care for the treatment of cystic fibrosis, it is doubtful that PTI-428 will help patients or even pass its phase 3 trials.

http://www.zerohedge.com/news/2016-04-21/notorious-short-seller-raises-100-million-take-down-unknown-company

https://www.linkedin.com/in/sahm-adrangi

Fortress Investment Group Agrees to Sale OneMain Holdings Inc.

Global conglomerate Fortress Investment Group agrees to sell their stake in OneMain Holding Incorporated for $1.4 billion. Fortress Investment Group has agreed in principle to the sale of OneMain to Varde Partners and Apollo Global Management LLC for $26 a share. Fortress is selling there 40.5% position in OneMain Holding and with this sale will be divesting a large subprime asset from their portfolio.

Fortress Investment Group has made extraordinary returns on investment by investing in subprime lending and other alternative asset vehicles. Currently, Fortress Investment Group has more than $30 billion in assets under management for their individual and institutional clients from around the globe. Their executive team consists of Co-Chief Executive Officers Peter Briger and Wes Edens who leads the company into its various investment opportunities with a high level of analysis and evaluation expertise that generates excellent results.

Peter Briger, in particular, runs the Fortress Credit business by capitalizing on various alternative asset classes that are distressed, underperforming, and illiquid opportunities that generally translate into very profitable investment endeavors. Wes Edens the current co-owner of the Milwaukee Bucks is also an innovator in the alternative asset industry and provides guidance over the private equity and other capital investment opportunities. The investment in OneMain Holdings was one of the opportunities for Fortress Investment Group to solidify its position within the subprime lending category.

OneMain Holding Incorporated specializes in providing subprime loans to the general public that have less than perfect credit dynamics, which is encompasses most of the general population and provides needed capital for regular individuals nationwide. OneMain also specializes in loans for operating funding for small business owners to continue and expand there their business with the necessary capital resources. With the guidance of Fortress Investment Group and their intellectual resources, analysis, and evaluation capabilities OneMain has progressed into a premier subprime lender in the nation. Fortress Investment Group was sold to SoftBank Group a global technology firm that specializes in internet service, telecommunications, AI, robotics and other specialized technology innovations that are propelling the world into the new information revolution.

As a subsidiary of SoftBank Group, Fortress Investment Group continues to make strategic insightful decisions that provide their clients with lucrative returns on investment. The sale of OneMain by Fortress will be the loss of a major subprime lending company from their portfolio but will generate a great return on investment with the $1.4 billion purchase price they will receive.

Peter Briger at Fortress Investment Group continues to provide high-level analysis and evaluation skill sets that are translating into exceptional opportunities for profitable windfalls for the organization. The shrewd decisions to buy underperforming and distressed companies is done by Peter Briger and the other knowledgeable professionals at Fortress that provide the intellectual leadership and experience to translate the organizations into throbbing profitable companies.

Peter has created a blueprint for generating high rates of return for investment companies. The sale of OneMain Holdings Incorporated will provide Fortress Investment Group with additional capital resources to re-invest in other distressed opportunities and capitalize on those investments by providing exceptional opportunities for larger returns on investment for its clients.

Read More: www.crunchbase.com/person/randal-nardone

Jose Hawilla, Breaks Loose and Soars Higher In Sports Business Ventures

For one to become a successful business entrepreneur, two possible qualities can make them succeed. Some people are born with the natural acumen for business. They possess an almost innate trait that helps them make decisions that help the business grow. However, others may not be so lucky; they are not entrepreneurs until they are tailored to become. Successful entrepreneurship requires learning from the best and the worst. If you are not born an entrepreneur, you can still become successful in the field if you are willing to seek knowledge.

The Difference Between Entrepreneurship And Employment

There is an innate desire to be independent by entrepreneurs. The latter is a key difference between entrepreneurs and employees. The strong urge to take initiative stirs the energy in an entrepreneur to explore their abilities to make a difference to unlimited stretches. An entrepreneur doesn’t mind working for long hours to achieve what is on their mind. Entrepreneurs are a frustrated lot in large organizations; organizations can’t let them speak out their mind. Jose Hawilla could not stand it.

Jose Hawilla’s Background

Jose Hawilla was born somewhere in the state of Sao Paulo. He is an entrepreneur, who before his business ventures worked as a journalist and a successful one at that. Traffic, which he owns, is, arguably, the most successful marketing company for sports in Brazil.

Jose Hawilla is a family man. He is married with three children. One of his children is closely following in his footsteps, career-wise. Like other entrepreneurs starting out, Jose Hawilla faced a myriad of challenges. He particularly cites instances of overt pessimism from those who never knew that one could make money out of sports. Again, like the natural entrepreneur he is, he saw an opportunity to prove them wrong, and he did. For more details visit LinkedIn.

Jose Hawilla’s Stature and Business Conquests

In fact, Jose Hawilla is currently highly rated as one of the most influential Brazilians. Mr. Jose Hawilla also owns the affiliates of Rede Globo; a network of successful newspapers in the inner locations of Sao Paulo. Some of the newspapers under the network include Bom Dia Bauru, Good Morning Fernandopolis, Good Morning Catanduva among others. He has since made several inroads in the world of entrepreneurship and acquired other significant business entities such as Diario De Sao Paulo.

His Journalism Days

Jose Hawilla acquired his ideas from his journalism activities back in the day. He was a radio and television reporter for ten years. He rose through the ranks and became a producer of programs while he worked as a commentator too. Jose Hawilla has a degree in Law.

See more: http://www.traffic.com.br/

The Larkin and Lacey Frontera Fund Aims at Correcting Societal Injustices

The Larkin and Lacey Frontera Fund was founded by two journalists, Jim Larkin and Michael Lacey. These two got arrested for providing online information on the injustices committed by local authorities. Joe Arpaio, the sheriff in question, went to their homes at night to arrest them for crimes they did not commit. Learn more about Michael Lacey and Jim Larkin: http://www.bizjournals.com/phoenix/potmsearch/detail/submission/6427818/Michael_Lacey

Upon hearing of the case, they were proved innocent by the court of law. Thus, they were awarded a settlement fee in form of compensation for accusing them falsely. It is this money that Michael Lacey and Jim Larkin used to establish Larkin and Lacey Frontera Fund.

Since the initiation of the organization, the Larkin and Lacey Frontera Fund has helped in correcting injustices within the society. Michael Lacey and Jim Larkin have achieved this by chanelling donations and funds to organizations that fight for human and immigrants’ rights. One of the civil organizations that the Larkin and Lacey Frontera Fund has donated to is the Arizona Justice Project.

The Arizona Justice Project focuses on correcting the societal wrongs. Also, they are committed towards achieving justice for the people of Arizona who cannot fight for their rights on their own. Most of all, the organization has promoted the settlement of immigrants in the United States of America despite the strict laws at the country’s borders. All these have been possible due to the support that Arizona Justice Project has been receiving from The Lacey and Larkin Frontera Fund.

However, one of the most recent projects that Jim Larkin and Michael Lacey are working on is the rooting of organizations that support children of immigrants.

The Lacey and Larkin Frontera Fund is helping the Arizona DREAMers in fighting for the Deferred Action for Childhood Arrivals (DACA). DACA is committed towards finding employment opportunities for immigrants.

Also, assists parents to find good school in the United States of America for their children. The organization is facing some challenges following the strict rules that the Donald Trump, the president of the United States of America amended against immigrants.

These state regulations aim at eliminating DACA. Michael Lacey and Jim Larkin have put up initiatives in the hope of finding justice for the organization.

In the light of this, they are confident that Donald Trump will somehow bend the rules in favour of the immigrants. Indeed, The Lacey and Larkin Frontera Fund have supported many organizations hence helping them achieve their dreams.

Read more:

Michael Lacey | Crunchbase
Phoenix New Times | Wikipedia

David McDonalds Leadership at the OSI Group

David M Donald is currently the Chief Operating Officer (COO) of ISO GROUP which is based in Aurora. ISO Group supplies food services and retail to brand across the world.it is also an international premier supplier McDonald says that the company is well position in a global setting. The company has branches in 17 countries with over 20,000 and above employees. The employees focus on making the customer satisfaction is delivered with their range of quality varieties that are offered.

David M Donald Graduated from Lowa State University in 1987 with Bachelors of science degree specializing in Animal science. After his graduation, David M Donald joined ISO group where he has raised in the rank throughout the years. He served as Chairman of North America Meat Institute. He also served as an independent Director at Marfrig Global Foods in South Africa since 2008 December. During his tenure in ISO David McDonald with ISO china supplied with over 100 tons of assorted food products during the Beijing Olympic Games. These include; beef, eggs, chicken, pork, and onion dehydrated. At this time the company was highly appreciated, and it was stamped for providing with the incredible service.

With his experience in the food industry David McDonald has not only gotten customers trust but it has become a favorite joint. Throughout the year and through his leadership he has acquired several companies to help in strengthening its brand and reaching more customers. It is through his hard work that McDonald has achieved all that he has it’s of great value that society can see and copy the ethical values that he has set.

During McDonald’s leadership, he has been able to sustain and improve sustainability. In 2016 a report from Global Sustainability was released, and ISO showed significant progress made in detail based on the supply chain. The supply chain is key to every organization and keeping. The report outlined that the company had a 2020 goal of 10% energy reduction and water sustainability. All the ISO facilities in the US have attained the ISO certification. And it has donated food to over100 metric tons by North America was given to the homeless and low-income family in the Philippines.

David McDonald has a noble heard and he has decided to go out of his way to give back to the society in doing that he has managed to reach the less privileged in the community and provided them with the most basic stuff, food.

To know more click: here.

Larkin and Lacey Provide Help for Civil Rights Cases

Civil rights and human rights cases can be complicated. Those who go through them often have a long road they have to go down, and it can be complicated to deal with everything there is to happen with these cases.

Most times, the people who are dealing with the cases don’t have the money to help support themselves during the cases. They also often do not even have the money that would be required to fight the charges that are coming from the case so they just take them instead of trying to fight for their own rights.

This is a major problem in the United States, and it is something that most people are aware of. While the people are aware of it, very few are doing anything to stop it from happening in the future. Read more: Michael Lacey | Crunchbase and Michael Lacey | Facebook

They want to show people they care about them, but they don’t want to have to take action. Larkin and Lacey, though, have always wanted to take action to help support minorities. They dedicated their entire career to the help they could give to people, and it is what made them the activists that they are today.

Since things continue to get worse for minorities in the United States, Larkin and Lacey wanted to show people things could get better. They even dealt with their own human rights issues during the time while a sheriff’s office tried to charge them with just practicing one of their constitutional rights.

It was difficult for the men, but they got through it and won the case. Since they had the money to fight it, it made things easier for them to be able to win in the case they were dealing with.

As things continued to change and Larkin and Lacey knew they would have to do more to help others out, they made sure they were doing things the right way. They even started their foundation with the goal of helping others out who did not have the same type of help they did.

They wanted minorities to be able to fight violations and get the rights they needed. Larkin and Lacey even do what they can to help immigrants and those who are trying to come to the United States. They do this so they will have a chance to show people what they are entitled to in the country they are a part of.

The Top Performers are Recognized in Adam Goldenberg’s Business

In TechStyle, the employee who is giving his all is the one that is getting most recognition. This is one of the reasons that it is one of the best places to work. There are too many companies where the hardest and most passionate worker is overlooked for some of the people that are lagging. When people are recognized for their hard work, they are encouraged to put in even more work. This is one of the reasons that TechStyle remains so effective. Adam Goldenberg understands the importance of recognizing good behavior as well as behavior that needs to be corrected.

 

One thing that Adam Goldenberg notices with other companies is that managers spend so much time on the employees that are working at a B level. However Adam Goldenberg does things a little different. All of his employees are not B level performers. Adam Goldenberg only keeps the A level performers with the intention of helping them grow. This is one of the reasons that he looks at the passion that the candidate has for the company. If the company is passionate, then he is more likely to perform well as long as that passion is also tempered with humility.

 

One thing that Adam Goldenberg wants to do is keep his team focused and engaged. After a while, even the most fun companies can lose the engagement of employees. This is one of the reasons that Adam Goldenberg keeps with the mentoring of his top level performers. In the fashion industry, it is important for people to be engaged so that they can come up with some engaging designs that will bring in all of the sales from the customers. This is one of the reasons that Adam Goldenberg has “be passionate” as one of the mantras in his office. http://www.entrepreneur.wiki/Adam_Goldenberg

 

One thing that is not going to take any business anywhere is a lazy attempt at work. People who do not have their whole mind set to working for their company are not going to take it anywhere. This is one of the reasons that the top performers are given a lot of recognition.

Chris Burch Explores the Word of Tech Fashion

There has been a ton of advancements in both the fashion and technological industry in the recent past. The most interesting thing is that the two fields are growing in an almost similar manner. Technology is becoming part of fashion, and very few people would be caught walking around with technology that is unfashionable.

 

Chris Burch believes that it is time for the two to marry and create high standards of functionality and innovation that will drive the market to the next level. Up to now, technology has just been but practical. Marrying it to fashion will give use good looking products that are even more practical.

 

We envision a future where no one will ignore functional ware simply because it is inconveniencing or unfashionable. Think of a biker airbag that stays around your neck and out of your peripheral vision as you ride and only inflates to protect you when it detects a tumble. This will be easier to wear and most people will count on it to keep them safe during the fewer accidents thanks to better hearing and visibility.

 

About Chris Burch

 

Chris (Christopher) Burch is the founder and current CEO of the Burch Creative Capital, a company that invests in new markets and works on imagination, creativity and incubation to come up with impressive innovations that have a true positive impact on the consumer market.

 

Mr Burch has participated in the inception and growth of up to 50 companies in his almost 40 years career and is an expert in combining consumer behavior with innovators and thinkers to come up with practical solutions for the practical world.

 

His latest efforts can be seen in the manifestation of a couple of ED portfolios by Ellen DeGeneres, Nihiwatu, Poppin and TRADEMARK. This is just but an addition to the vast list of established brands that have gone through the highly capable hands of Chris Burch.